Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination...

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Bibliographic Details
Main Authors: Chaopei Zhou, Xiuxiu Dong, Chunxiang Song, Shuang Cui, Tiantian Chen, Daji Zhang, Xiuli Zhao, Chunrong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hyaluronic acid
mixed micelle
chemo-immunotherapy combinations
drug delivery system
programmed cell death ligand 1 (PD-L1)
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.653417/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.653417/full

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