The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia

The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia

Background: The apolipoprotein E ε4 gene variant (APOEε4) confers considerable risk for dementia and affects neuroinflammation, brain metabolism, and synaptic function. The kynurenine pathway (KP) gives rise to neuroactive metabolites, which have inflammatory, redox, and excitotoxic effects in the b...

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Bibliographic Details
Main Authors: Arne Olav Ervik, Stein-Erik Hafstad Solvang, Jan Erik Nordrehaug, Per Magne Ueland, Øivind Midttun, Audun Hildre, Adrian McCann, Ottar Nygård, Dag Aarsland, Lasse Melvaer Giil
Format: Article
Language:English
Published: SAGE Publishing 2019-11-01
Series:International Journal of Tryptophan Research
Online Access:https://doi.org/10.1177/1178646919885637

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https://doi.org/10.1177/1178646919885637

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