Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway

Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway

The human islet amyloid polypeptide (hIAPP), the major component of islet amyloid deposition, is one of the amyloidogenic peptides and has been associated with β cell loss and dysfunction in type 2 diabetes (T2D). Autophagy plays a central role in the clearance of hIAPP aggregates, thereby diminishi...

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Bibliographic Details
Main Authors: Jianzhen Lin, Ao Jiao, Wu Lv, Chengshuo Zhang, Yue Shi, Zhaoming Yang, Ning Sun, Xiaohang Li, Jialin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
human islet amyloid polypeptide
peptide inhibitor
autophagy
mTOR
islet
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00896/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00896/full

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