Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases

Caenorhabditis elegans has a number of distinct advantages that are useful for understanding the basis for cellular and organismal dysfunction underlying age-associated diseases of protein misfolding. Although protein aggregation, a key feature of human neurodegenerative diseases, has been typically...

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Bibliographic Details
Main Authors: Carmen I. Nussbaum-Krammer, Richard I. Morimoto
Format: Article
Language:English
Published: The Company of Biologists 2014-01-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/7/1/31