An assessment of the potential miscalibration of cardiovascular disease risk predictions caused by a secular trend in cardiovascular disease in England

Abstract Background A downwards secular trend in the incidence of cardiovascular disease (CVD) in England was identified through previous work and the literature. Risk prediction models for primary prevention of CVD do not model this secular trend, this could result in over prediction of risk for in...

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Bibliographic Details
Main Authors: Alexander Pate, Tjeerd van Staa, Richard Emsley
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-020-01173-x