Design principles for enhancing phase sensitivity and suppressing phase fluctuations simultaneously in biochemical oscillatory systems

Biochemical processes require both high sensitivity and low fluctuation which is incompatible with the fluctuation dissipation theorem. Here Fei et al. model biochemical oscillators to show how free energy dissipation leads to both a suppression of phase fluctuation and an enhancement of phase sensi...

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Bibliographic Details
Main Authors: Chenyi Fei, Yuansheng Cao, Qi Ouyang, Yuhai Tu
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03826-4