γ-Selective C(sp3)–H amination via controlled migratory hydroamination

Sequential alkene isomerization and cross-coupling enables remote functionalization, but coupling has been limited to positions at a carbon chain terminus or proximal to a functional group. Here the authors show a method to interrupt isomerization with a nickellacycle, which enables coupling at an a...

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Bibliographic Details
Main Authors: Changseok Lee, Huiyeong Seo, Jinwon Jeon, Sungwoo Hong
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25696-z