Neuronal Parasitism, Early Myenteric Neurons Depopulation and Continuous Axonal Networking Damage as Underlying Mechanisms of the Experimental Intestinal Chagas' Disease

Neuronal Parasitism, Early Myenteric Neurons Depopulation and Continuous Axonal Networking Damage as Underlying Mechanisms of the Experimental Intestinal Chagas' Disease

There is a growing consensus that the balance between the persistence of infection and the host immune response is crucial for chronification of Chagas heart disease. Extrapolation for chagasic megacolon is hampered because research in humans and animal models that reproduce intestinal pathology is...

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Bibliographic Details
Main Authors: Mayra Fernanda Ricci, Samantha Ribeiro Béla, Michele Macedo Moraes, Maria Terezinha Bahia, Ana Lia Mazzeti, Anny Carolline Silva Oliveira, Luciana Oliveira Andrade, Rafael Radí, Lucía Piacenza, Rosa Maria Esteves Arantes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma cruzi
pathogenesis
intestinal chagas's disease
experimental model
nitric oxide (NO)
reactive species
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.583899/full

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https://www.frontiersin.org/article/10.3389/fcimb.2020.583899/full

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