Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells

Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells

Mice lacking the core-clock components, cryptochrome-1 (CRY1) and cryptochrome-2 (CRY2) display a phenotype of hyperaldosteronism, due to the upregulation of type VI 3β-hydroxyl-steroid dehydrogenase (Hsd3b6), the murine counterpart to the human type I 3β-hydroxyl-steroid dehydrogenase (HSD3B1) gene...

Full description

Bibliographic Details
Main Authors: Martina Tetti, Isabella Castellano, Francesca Veneziano, Corrado Magnino, Franco Veglio, Paolo Mulatero, Silvia Monticone
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
aldosterone-producing adenoma
CRY1
CRY2
HSD3B1
HSD3B2
Online Access:http://www.mdpi.com/1422-0067/19/6/1675

Internet

http://www.mdpi.com/1422-0067/19/6/1675

Similar Items