MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α

MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α

Abstract Background T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) expression was...

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Bibliographic Details
Main Authors: Li Xu, Wen J. Sun, Ai J. Jia, Lu L. Qiu, Bing Xiao, Lin Mu, Jian M. Li, Xiu F. Zhang, Yan Wei, Cong Peng, Dong S. Zhang, Xu D. Xiang
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Inflammation
Subjects:
Neutrophils-dominant asthma
Hypoxia inducible factor-1α
Methtyl-CpG binding domain protein 2
T helper 17 cells
Online Access:http://link.springer.com/article/10.1186/s12950-018-0191-x

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http://link.springer.com/article/10.1186/s12950-018-0191-x

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