The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders

Antenatal glucocorticoid therapy is indicated for mothers at risk of preterm delivery. Here, the authors show that the circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders later in life in mice and in a retrospective observational study in human infants.

Bibliographic Details
Main Authors: Mariana Astiz, Isabel Heyde, Mats Ingmar Fortmann, Verena Bossung, Claudia Roll, Anja Stein, Berthold Grüttner, Wolfgang Göpel, Christoph Härtel, Jonas Obleser, Henrik Oster
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17429-5