Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

Retroviruses by definition insert their viral genome into the host cell chromosome. Although the key player of retroviral integration is viral integrase, a role for cellular cofactors has been proposed. Lentiviral integrases use the cellular protein LEDGF/p75 to tether the preintegration complex to...

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Bibliographic Details
Main Authors: Anneleen Hombrouck, Jan De Rijck, Jelle Hendrix, Linos Vandekerckhove, Arnout Voet, Marc De Maeyer, Myriam Witvrouw, Yves Engelborghs, Frauke Christ, Rik Gijsbers, Zeger Debyser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC1839165?pdf=render

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http://europepmc.org/articles/PMC1839165?pdf=render

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