TDP-43 regulates endogenous retrovirus-K viral protein accumulation

The concomitant expression of neuronal TAR DNA binding protein 43 (TDP-43) and human endogenous retrovirus-K (ERVK) is a hallmark of ALS. Since the involvement of TDP-43 in retrovirus replication remains controversial, we sought to evaluate whether TDP-43 exerts an effect on ERVK expression. In this...

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Bibliographic Details
Main Authors: Mamneet Manghera, Jennifer Ferguson-Parry, Renée N. Douville
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301565