Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies

Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies

Abstract Background Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use external weights from an independen...

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Bibliographic Details
Main Authors: Anke Hüls, Ursula Krämer, Christopher Carlsten, Tamara Schikowski, Katja Ickstadt, Holger Schwender
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Genetics
Subjects:
Polygenic approach
Training dataset
Internal weights
External weights
Simulation study
Power
Online Access:http://link.springer.com/article/10.1186/s12863-017-0586-3

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http://link.springer.com/article/10.1186/s12863-017-0586-3

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