The Efficacy of the Quorum Sensing Inhibitor FS8 and Tigecycline in Preventing Prosthesis Biofilm in an Animal Model of Staphylococcal Infection

The Efficacy of the Quorum Sensing Inhibitor FS8 and Tigecycline in Preventing Prosthesis Biofilm in an Animal Model of Staphylococcal Infection

We investigated the efficacy of tigecycline and FS8, alone or combined, in preventing prosthesis biofilm in a rat model of staphylococcal vascular graft infection. Graft infections were established in the back subcutaneous tissue of adult male Wistar rats by implantation of Dacron prostheses followe...

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Bibliographic Details
Main Authors: Andrea Giacometti, Annamaria Offidani, Erika Fornasari, Marco Vivarelli, Pamela Castelli, Mauro Provinciali, Fiorenza Orlando, Leonardo Baldassarre, Carmela Silvestri, Ivana Cacciatore, Oriana Simonetti, Oscar Cirioni, Federico Mocchegiani
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:International Journal of Molecular Sciences
Subjects:
lipopeptides
tigecycline
FS8
vascular graft infection
bacterial biofilm
Online Access:http://www.mdpi.com/1422-0067/14/8/16321

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http://www.mdpi.com/1422-0067/14/8/16321

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