A Sub-Clone of RAW264.7-Cells Form Osteoclast-Like Cells Capable of Bone Resorption Faster than Parental RAW264.7 through Increased De Novo Expression and Nuclear Translocation of NFATc1

A Sub-Clone of RAW264.7-Cells Form Osteoclast-Like Cells Capable of Bone Resorption Faster than Parental RAW264.7 through Increased De Novo Expression and Nuclear Translocation of NFATc1

The murine macrophage cell line RAW264.7 is extensively used as a progenitor to study osteoclast (OC) differentiation. RAW264.7 is a heterogeneous cell line, containing sub-clones with different abilities to form OCs. The aim of this study was to identify characteristics within the heterogeneous RAW...

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Bibliographic Details
Main Authors: Laia Mira-Pascual, Anh N. Tran, Göran Andersson, Tuomas Näreoja, Pernilla Lång
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
osteoclast
raw264.7
tartrate-resistant acid phosphatase
osteoclastogenesis
bone resorption
nfatc1
differentiation
Online Access:https://www.mdpi.com/1422-0067/21/2/538

Internet

https://www.mdpi.com/1422-0067/21/2/538

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