In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.

In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.

BACKGROUND: The leishmaniases are a complex of neglected tropical diseases caused by more than 20 Leishmania parasite species, for which available therapeutic arsenal is scarce and unsatisfactory. Pentavalent antimonials (SbV) are currently the first-line pharmacologic therapy for leishmaniasis worl...

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Main Authors: Rubén E Varela-M, Janny A Villa-Pulgarin, Edward Yepes, Ingrid Müller, Manuel Modolell, Diana L Muñoz, Sara M Robledo, Carlos E Muskus, Julio López-Abán, Antonio Muro, Iván D Vélez, Faustino Mollinedo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3323514?pdf=render

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http://europepmc.org/articles/PMC3323514?pdf=render

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