TIGIT Induces (CD3+) T Cell Dysfunction in Colorectal Cancer by Inhibiting Glucose Metabolism

TIGIT Induces (CD3+) T Cell Dysfunction in Colorectal Cancer by Inhibiting Glucose Metabolism

T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is an immunosuppressive receptor expressed on the surface of immune cells, suppressing immune responses by activating the intracellular negative regulatory signals. TIGIT plays an important role in the pathogenes...

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Bibliographic Details
Main Authors: Qi Shao, Lei Wang, Maoling Yuan, Xiaohong Jin, Zhiming Chen, Changping Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
TIGIT
colorectal cancer
immunotherapy
tumor microenvironment
CD3+ T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.688961/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.688961/full

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