Ancient mtDNA genetic variants modulate mtDNA transcription and replication.

Ancient mtDNA genetic variants modulate mtDNA transcription and replication.

Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and whic...

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Bibliographic Details
Main Authors: Sarit Suissa, Zhibo Wang, Jason Poole, Sharine Wittkopp, Jeanette Feder, Timothy E Shutt, Douglas C Wallace, Gerald S Shadel, Dan Mishmar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2673036?pdf=render

Internet

http://europepmc.org/articles/PMC2673036?pdf=render

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