RetSynth: determining all optimal and sub-optimal synthetic pathways that facilitate synthesis of target compounds in chassis organisms

RetSynth: determining all optimal and sub-optimal synthetic pathways that facilitate synthesis of target compounds in chassis organisms

Abstract Background The efficient biological production of industrially and economically important compounds is a challenging problem. Brute-force determination of the optimal pathways to efficient production of a target chemical in a chassis organism is computationally intractable. Many current met...

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Bibliographic Details
Main Authors: Leanne S. Whitmore, Bernard Nguyen, Ali Pinar, Anthe George, Corey M. Hudson
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Bioinformatics
Subjects:
Mixed integer linear programming
Metabolic engineering
Flux balance analysis
Online Access:http://link.springer.com/article/10.1186/s12859-019-3025-9

Internet

http://link.springer.com/article/10.1186/s12859-019-3025-9

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