Potent inhibition of HIV-1 replication by a Tat mutant.
Herein we describe a mutant of the two-exon HIV-1 Tat protein, termed Nullbasic, that potently inhibits multiple steps of the HIV-1 replication cycle. Nullbasic was created by replacing the entire arginine-rich basic domain of wild type Tat with glycine/alanine residues. Like similarly mutated one-e...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-11-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2768900?pdf=render |