The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study
Abstract Introduction The Meta VCI Map consortium performs meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive les...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-12-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2019.02.007 |
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doaj-1aa346e2b88b413ba69d2ca3bb78ab8c |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nick A. Weaver Lei Zhao J. Matthijs Biesbroek Hugo J. Kuijf Hugo P. Aben Hee‐Joon Bae Miguel Á.A. Caballero Francesca M. Chappell Christopher P.L.H. Chen Martin Dichgans Marco Duering Marios K. Georgakis Ruben S. van derGiessen Bibek Gyanwali Olivia K.L. Hamilton Saima Hilal Elise M. vomHofe Paul L.M. deKort Peter J. Koudstaal Bonnie Y.K. Lam Jae‐Sung Lim Stephen D.J. Makin Vincent C.T. Mok Lin Shi Maria C. Valdés Hernández Narayanaswamy Venketasubramanian Joanna M. Wardlaw Frank A. Wollenweber Adrian Wong Xu Xin Meta VCI Map consortium C. DeCarli E.A. Fletcher P. Maillard J. Barnes C.H. Sudre J.M. Schott M.A. Ikram J.M. Papma R.M.E. Steketee M.W. Vernooij R. Bordet R. Lopes C.‐W. Huang R. Frayne C.R. McCreary E.E. Smith Calgary Normative Study group W. Backes S. Köhler R.J. vanOostenbrugge J. Staals F. Verhey C.Y. Cheng R.N. Kalaria D. Werring J.L. Hsu K.‐L. Huang J. van derGrond J.W. Jukema R.C. van derMast T.C.W. Nijboer Framingham Heart Study group K.‐H. Yu The Dutch Parelsnoer Institute – Neurodegenerative diseases group R. Schmidt L. Pirpamer B.J. MacIntosh A.D. Robertson F.‐E. deLeeuw A.M. Tuladhar N. Chaturvedi T. Tillin H. Brodaty P. Sachdev TABASCO group F. Barkhof W.M. van derFlier L.J. Kappelle Geert Jan Biessels |
| spellingShingle |
Nick A. Weaver Lei Zhao J. Matthijs Biesbroek Hugo J. Kuijf Hugo P. Aben Hee‐Joon Bae Miguel Á.A. Caballero Francesca M. Chappell Christopher P.L.H. Chen Martin Dichgans Marco Duering Marios K. Georgakis Ruben S. van derGiessen Bibek Gyanwali Olivia K.L. Hamilton Saima Hilal Elise M. vomHofe Paul L.M. deKort Peter J. Koudstaal Bonnie Y.K. Lam Jae‐Sung Lim Stephen D.J. Makin Vincent C.T. Mok Lin Shi Maria C. Valdés Hernández Narayanaswamy Venketasubramanian Joanna M. Wardlaw Frank A. Wollenweber Adrian Wong Xu Xin Meta VCI Map consortium C. DeCarli E.A. Fletcher P. Maillard J. Barnes C.H. Sudre J.M. Schott M.A. Ikram J.M. Papma R.M.E. Steketee M.W. Vernooij R. Bordet R. Lopes C.‐W. Huang R. Frayne C.R. McCreary E.E. Smith Calgary Normative Study group W. Backes S. Köhler R.J. vanOostenbrugge J. Staals F. Verhey C.Y. Cheng R.N. Kalaria D. Werring J.L. Hsu K.‐L. Huang J. van derGrond J.W. Jukema R.C. van derMast T.C.W. Nijboer Framingham Heart Study group K.‐H. Yu The Dutch Parelsnoer Institute – Neurodegenerative diseases group R. Schmidt L. Pirpamer B.J. MacIntosh A.D. Robertson F.‐E. deLeeuw A.M. Tuladhar N. Chaturvedi T. Tillin H. Brodaty P. Sachdev TABASCO group F. Barkhof W.M. van derFlier L.J. Kappelle Geert Jan Biessels The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Cerebrovascular disease Vascular cognitive impairment Stroke Small vessel disease Consortium Data harmonization |
| author_facet |
Nick A. Weaver Lei Zhao J. Matthijs Biesbroek Hugo J. Kuijf Hugo P. Aben Hee‐Joon Bae Miguel Á.A. Caballero Francesca M. Chappell Christopher P.L.H. Chen Martin Dichgans Marco Duering Marios K. Georgakis Ruben S. van derGiessen Bibek Gyanwali Olivia K.L. Hamilton Saima Hilal Elise M. vomHofe Paul L.M. deKort Peter J. Koudstaal Bonnie Y.K. Lam Jae‐Sung Lim Stephen D.J. Makin Vincent C.T. Mok Lin Shi Maria C. Valdés Hernández Narayanaswamy Venketasubramanian Joanna M. Wardlaw Frank A. Wollenweber Adrian Wong Xu Xin Meta VCI Map consortium C. DeCarli E.A. Fletcher P. Maillard J. Barnes C.H. Sudre J.M. Schott M.A. Ikram J.M. Papma R.M.E. Steketee M.W. Vernooij R. Bordet R. Lopes C.‐W. Huang R. Frayne C.R. McCreary E.E. Smith Calgary Normative Study group W. Backes S. Köhler R.J. vanOostenbrugge J. Staals F. Verhey C.Y. Cheng R.N. Kalaria D. Werring J.L. Hsu K.‐L. Huang J. van derGrond J.W. Jukema R.C. van derMast T.C.W. Nijboer Framingham Heart Study group K.‐H. Yu The Dutch Parelsnoer Institute – Neurodegenerative diseases group R. Schmidt L. Pirpamer B.J. MacIntosh A.D. Robertson F.‐E. deLeeuw A.M. Tuladhar N. Chaturvedi T. Tillin H. Brodaty P. Sachdev TABASCO group F. Barkhof W.M. van derFlier L.J. Kappelle Geert Jan Biessels |
| author_sort |
Nick A. Weaver |
| title |
The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study |
| title_short |
The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study |
| title_full |
The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study |
| title_fullStr |
The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study |
| title_full_unstemmed |
The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study |
| title_sort |
meta vci map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: design and multicenter pilot study |
| publisher |
Wiley |
| series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| issn |
2352-8729 |
| publishDate |
2019-12-01 |
| description |
Abstract Introduction The Meta VCI Map consortium performs meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion‐symptom mapping studies. Methods Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results Forty‐seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population‐based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join. |
| topic |
Cerebrovascular disease Vascular cognitive impairment Stroke Small vessel disease Consortium Data harmonization |
| url |
https://doi.org/10.1016/j.dadm.2019.02.007 |
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doaj-1aa346e2b88b413ba69d2ca3bb78ab8c2020-11-25T02:32:37ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292019-12-0111131032610.1016/j.dadm.2019.02.007The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot studyNick A. Weaver0Lei Zhao1J. Matthijs Biesbroek2Hugo J. Kuijf3Hugo P. Aben4Hee‐Joon Bae5Miguel Á.A. Caballero6Francesca M. Chappell7Christopher P.L.H. Chen8Martin Dichgans9Marco Duering10Marios K. Georgakis11Ruben S. van derGiessen12Bibek Gyanwali13Olivia K.L. Hamilton14Saima Hilal15Elise M. vomHofe16Paul L.M. deKort17Peter J. Koudstaal18Bonnie Y.K. Lam19Jae‐Sung Lim20Stephen D.J. Makin21Vincent C.T. Mok22Lin Shi23Maria C. Valdés Hernández24Narayanaswamy Venketasubramanian25Joanna M. Wardlaw26Frank A. Wollenweber27Adrian Wong28Xu Xin29Meta VCI Map consortiumC. DeCarli30E.A. Fletcher31P. Maillard32J. Barnes33C.H. Sudre34J.M. Schott35M.A. Ikram36J.M. Papma37R.M.E. Steketee38M.W. Vernooij39R. Bordet40R. Lopes41C.‐W. Huang42R. Frayne43C.R. McCreary44E.E. Smith45Calgary Normative Study group46W. Backes47S. Köhler48R.J. vanOostenbrugge49J. Staals50F. Verhey51C.Y. Cheng52R.N. Kalaria53D. Werring54J.L. Hsu55K.‐L. Huang56J. van derGrond57J.W. Jukema58R.C. van derMast59T.C.W. Nijboer60Framingham Heart Study group61K.‐H. Yu62The Dutch Parelsnoer Institute – Neurodegenerative diseases group63R. Schmidt64L. Pirpamer65B.J. MacIntosh66A.D. Robertson67F.‐E. deLeeuw68A.M. Tuladhar69N. Chaturvedi70T. Tillin71H. Brodaty72P. Sachdev73TABASCO group74F. Barkhof75W.M. van derFlier76L.J. Kappelle77Geert Jan Biessels78Department of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsBrainNow Medical Technology Limited, Hong Kong Science and Technology ParkShatinHong Kong SARChinaDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsImage Sciences Institute, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of NeurologySeoul National University Bundang HospitalSeongnamRepublic of KoreaInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermanyNeuroimaging SciencesCentre for Clinical Brain SciencesUniversity of EdinburghEdinburghUnited KingdomDepartment of PharmacologyNational University of SingaporeSingaporeSingaporeInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermanyInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermanyInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermanyDepartment of NeurologyErasmus Medical CenterRotterdamthe NetherlandsDepartment of PharmacologyNational University of SingaporeSingaporeSingaporeNeuroimaging SciencesCentre for Clinical Brain SciencesUniversity of EdinburghEdinburghUnited KingdomDepartment of PharmacologyNational University of SingaporeSingaporeSingaporeDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of NeurologyElisabeth Tweesteden HospitalTilburgthe NetherlandsDepartment of NeurologyErasmus Medical CenterRotterdamthe NetherlandsDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of NeurologyHallym University Sacred Heart HospitalAnyangRepublic of KoreaInstitute of Cardiovascular and Medical Sciences, University of GlasgowGlasgowUnited KingdomDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaBrainNow Medical Technology Limited, Hong Kong Science and Technology ParkShatinHong Kong SARChinaNeuroimaging SciencesCentre for Clinical Brain SciencesUniversity of EdinburghEdinburghUnited KingdomRaffles Neuroscience Centre, Raffles HospitalSingaporeSingaporeNeuroimaging SciencesCentre for Clinical Brain SciencesUniversity of EdinburghEdinburghUnited KingdomInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermanyDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of PharmacologyNational University of SingaporeSingaporeSingaporeDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsDepartment of Neurology and NeurosurgeryUMC Utrecht Brain Center, University Medical Center UtrechtUtrechtthe NetherlandsAbstract Introduction The Meta VCI Map consortium performs meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion‐symptom mapping studies. Methods Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results Forty‐seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population‐based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.https://doi.org/10.1016/j.dadm.2019.02.007Cerebrovascular diseaseVascular cognitive impairmentStrokeSmall vessel diseaseConsortiumData harmonization |