Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia

by Dorothe Burggraf, Andreas Trinkl, Martin Dichgans, Gerhard F. Hamann
Published 2007-03-01

Circulating biomarkers of immunity and inflammation, risk of Alzheimer’s disease, and hippocampal volume: a Mendelian randomization study

by Lana Fani, Marios K. Georgakis, M. Arfan Ikram, M. Kamran Ikram, Rainer Malik, Martin Dichgans
Published 2021-05-01

ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.

by Bence Gunda, Raphael Porcher, Marco Duering, Jean-Pierre Guichard, Jerome Mawet, Eric Jouvent, Martin Dichgans, Hugues Chabriat
Published 2014-01-01

Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing

by Isabel Weisheit, Joseph A. Kroeger, Rainer Malik, Julien Klimmt, Dennis Crusius, Angelika Dannert, Martin Dichgans, Dominik Paquet
Published 2020-05-01

Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals

by Davina Biel, Matthias Brendel, Anna Rubinski, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Nicolai Franzmeier, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Published 2021-08-01

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

by Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Rainer Malik, Michael Ewers
Published 2021-06-01

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

by Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S. Butterworth, Joanna M. M. Howson, Michael Inouye, Martin Dichgans
Published 2019-12-01

Author Correction: Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

by Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S. Butterworth, Joanna M. M. Howson, Michael Inouye, Martin Dichgans
Published 2020-02-01

Different Types of White Matter Hyperintensities in CADASIL

by Edouard Duchesnay, Fouad Hadj Selem, François De Guio, Mathieu Dubois, Jean-François Mangin, Marco Duering, Stefan Ropele, Reinhold Schmidt, Martin Dichgans, Hugues Chabriat, Hugues Chabriat, Hugues Chabriat, Eric Jouvent, Eric Jouvent, Eric Jouvent
Published 2018-07-01

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

by Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q. Trojanowski, Martin Dichgans, Gernot Kleinberger, Christian Haass, Michael Ewers, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Published 2020-10-01

PRediction of acute coronary syndrome in acute ischemic StrokE (PRAISE) – protocol of a prospective, multicenter trial with central reading and predefined endpoints

by Christian H. Nolte, Regina von Rennenberg, Simon Litmeier, Jan F. Scheitz, David M. Leistner, Stephan Blankenberg, Martin Dichgans, Hugo Katus, Gabor C. Petzold, Burkert Pieske, Vera Regitz-Zagrosek, Karl Wegscheider, Andreas M. Zeiher, Ulf Landmesser, Matthias Endres
Published 2020-08-01

The left frontal cortex supports reserve in aging by enhancing functional network efficiency

by Nicolai Franzmeier, Julia Hartmann, Alexander N. W. Taylor, Miguel Á. Araque-Caballero, Lee Simon-Vermot, Lana Kambeitz-Ilankovic, Katharina Bürger, Cihan Catak, Daniel Janowitz, Claudia Müller, Birgit Ertl-Wagner, Robert Stahl, Martin Dichgans, Marco Duering, Michael Ewers
Published 2018-03-01

Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden

by Marco Duering, Marek J. Konieczny, Steffen Tiedt, Ebru Baykara, Anil Man Tuladhar, Esther van Leijsen, Philippe Lyrer, Stefan T. Engelter, Benno Gesierich, Melanie Achmüller, Christian Barro, Ruth Adam, Michael Ewers, Martin Dichgans, Jens Kuhle, Frank-Erik de Leeuw, Nils Peters
Published 2018-05-01

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation

by Michael Ewers, Gloria Biechele, Marc Suárez‐Calvet, Christian Sacher, Tanja Blume, Estrella Morenas‐Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Matthias Brendel, Christian Haass, Nicolai Franzmeier
Published 2020-09-01

Mendelian randomization for studying the effects of perturbing drug targets [version 2; peer review: 2 approved, 1 approved with reservations]

by Dipender Gill, Marios K. Georgakis, Venexia M. Walker, A. Floriaan Schmidt, Apostolos Gkatzionis, Daniel F. Freitag, Chris Finan, Aroon D. Hingorani, Joanna M.M. Howson, Stephen Burgess, Daniel I. Swerdlow, George Davey Smith, Michael V. Holmes, Martin Dichgans, Robert A Scott, Jie Zheng, Bruce M. Psaty, Neil M. Davies
Published 2021-02-01

Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project

by Gordon W. Blair, Michael S. Stringer, Michael J. Thrippleton, Francesca M. Chappell, Kirsten Shuler, Iona Hamilton, Daniela Jaime Garcia, Fergus N. Doubal, Anna Kopczak, Marco Duering, Michael Ingrisch, Danielle Kerkhofs, Julie Staals, Hilde van den Brink, Tine Arts, Walter H Backes, Robert van Oostenbrugge, Geert Jan Biessels, Martin Dichgans, Joanna M. Wardlaw
Published 2021-01-01

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

by Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz
Published 2021-04-01

Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting

by Christos Kontos, Omar El Bounkari, Christine Krammer, Dzmitry Sinitski, Kathleen Hille, Chunfang Zan, Guangyao Yan, Sijia Wang, Ying Gao, Markus Brandhofer, Remco T. A. Megens, Adrian Hoffmann, Jessica Pauli, Yaw Asare, Simona Gerra, Priscila Bourilhon, Lin Leng, Hans-Henning Eckstein, Wolfgang E. Kempf, Jaroslav Pelisek, Ozgun Gokce, Lars Maegdefessel, Richard Bucala, Martin Dichgans, Christian Weber, Aphrodite Kapurniotu, Jürgen Bernhagen
Published 2020-11-01

Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.

by Emily Baker, Rebecca Sims, Ganna Leonenko, Aura Frizzati, Janet C Harwood, Detelina Grozeva, GERAD/PERADES, CHARGE, ADGC, EADI, IGAP consortia, Kevin Morgan, Peter Passmore, Clive Holmes, John Powell, Carol Brayne, Michael Gill, Simon Mead, Paola Bossù, Gianfranco Spalletta, Alison M Goate, Carlos Cruchaga, Wolfgang Maier, Reinhard Heun, Frank Jessen, Oliver Peters, Martin Dichgans, Lutz FröLich, Alfredo Ramirez, Lesley Jones, John Hardy, Dobril Ivanov, Matthew Hill, Peter Holmans, Nicholas D Allen, B Paul Morgan, Sudha Seshadri, Gerard D Schellenberg, Philippe Amouyel, Julie Williams, Valentina Escott-Price
Published 2019-01-01

A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.

by Matthew Traylor, Kari-Matti Mäkelä, Laura L Kilarski, Elizabeth G Holliday, William J Devan, Mike A Nalls, Kerri L Wiggins, Wei Zhao, Yu-Ching Cheng, Sefanja Achterberg, Rainer Malik, Cathie Sudlow, Steve Bevan, Emma Raitoharju, METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2), Niku Oksala, Vincent Thijs, Robin Lemmens, Arne Lindgren, Agnieszka Slowik, Jane M Maguire, Matthew Walters, Ale Algra, Pankaj Sharma, John R Attia, Giorgio B Boncoraglio, Peter M Rothwell, Paul I W de Bakker, Joshua C Bis, Danish Saleheen, Steven J Kittner, Braxton D Mitchell, Jonathan Rosand, James F Meschia, Christopher Levi, Martin Dichgans, Terho Lehtimäki, Cathryn M Lewis, Hugh S Markus
Published 2014-07-01