Cerebrospinal Fluid Biomarkers for Differentiation of Frontotemporal Lobar Degeneration from Alzheimer’s Disease

by David J Irwin, John Q Trojanowski, John Q Trojanowski, Murray eGrossman
Published 2013-02-01

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

by Michael X. Henderson, Medha Sengupta, John Q. Trojanowski, Virginia M. Y. Lee
Published 2019-11-01

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons

by Michael X. Henderson, Chao Peng, John Q. Trojanowski, Virginia M. Y. Lee
Published 2018-05-01

Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia

by Maiko T. Uemura, Maiko T. Uemura, Takakuni Maki, Masafumi Ihara, Virginia M. Y. Lee, John Q. Trojanowski
Published 2020-04-01

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

by Kurt R. Brunden, Virginia M-Y. Lee, Amos B. Smith, III, John Q. Trojanowski, Carlo Ballatore
Published 2017-09-01

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies

by Ethan W. Hass, Zachary A. Sorrentino, Yuxing Xia, Grace M. Lloyd, John Q. Trojanowski, Stefan Prokop, Benoit I. Giasson
Published 2021-08-01

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

by Hien T. Tran, Charlotte Hiu-Yan Chung, Michiyo Iba, Bin Zhang, John Q. Trojanowski, Kelvin C. Luk, Virginia M.Y. Lee
Published 2014-06-01

Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis.

by Johannes Brettschneider, Jon B Toledo, Vivianna M Van Deerlin, Lauren Elman, Leo McCluskey, Virginia M-Y Lee, John Q Trojanowski
Published 2012-01-01

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

by Michael X. Henderson, Medha Sengupta, Ian McGeary, Bin Zhang, Modupe F. Olufemi, Hannah Brown, John Q. Trojanowski, Virginia M. Y. Lee
Published 2019-02-01

Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration

by Lucia A. A. Giannini, Lucia A. A. Giannini, Lucia A. A. Giannini, Sharon X. Xie, Claire Peterson, Claire Peterson, Cecilia Zhou, Cecilia Zhou, Edward B. Lee, Edward B. Lee, David A. Wolk, Murray Grossman, John Q. Trojanowski, John Q. Trojanowski, Corey T. McMillan, David J. Irwin, David J. Irwin
Published 2019-07-01

Normalization of CSF pTau measurement by Aβ40 improves its performance as a biomarker of Alzheimer’s disease

by Tengfei Guo, Deniz Korman, Renaud La Joie, Leslie M. Shaw, John Q. Trojanowski, William J. Jagust, Susan M. Landau, for the Alzheimer’s Disease Neuroimaging Initiative
Published 2020-08-01

Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)...

by Garrett S. Gibbons, Soo-Jung Kim, John L. Robinson, Lakshmi Changolkar, David J. Irwin, Leslie M. Shaw, Virginia M.-Y. Lee, John Q. Trojanowski
Published 2019-03-01

Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies

by Amit Berson, Lindsey D. Goodman, Ashley N. Sartoris, Charlton G. Otte, James A. Aykit, Virginia M.-Y. Lee, John Q. Trojanowski, Nancy M. Bonini
Published 2019-04-01

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain

by Gabor G. Kovacs, Sharon X. Xie, John L. Robinson, Edward B. Lee, Douglas H. Smith, Theresa Schuck, Virginia M.-Y. Lee, John Q. Trojanowski
Published 2018-06-01

The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer's disease.

by Bianca A Trombetta, Becky C Carlyle, Aaron M Koenig, Leslie M Shaw, John Q Trojanowski, David A Wolk, Joseph J Locascio, Steven E Arnold
Published 2018-01-01

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

by Sílvia Porta, Yan Xu, Clark R. Restrepo, Linda K. Kwong, Bin Zhang, Hannah J. Brown, Edward B. Lee, John Q. Trojanowski, Virginia M.-Y. Lee
Published 2018-10-01

Relationship between plasma analytes and SPARE-AD defined brain atrophy patterns in ADNI.

by Jon B Toledo, Xiao Da, Priyanka Bhatt, David A Wolk, Steven E Arnold, Leslie M Shaw, John Q Trojanowski, Christos Davatzikos, Alzheimer’s Disease Neuroimaging Initiative
Published 2013-01-01

Astrocyte senescence as a component of Alzheimer's disease.

by Rekha Bhat, Elizabeth P Crowe, Alessandro Bitto, Michelle Moh, Christos D Katsetos, Fernando U Garcia, Frederick Bradley Johnson, John Q Trojanowski, Christian Sell, Claudio Torres
Published 2012-01-01

Integration and relative value of biomarkers for prediction of MCI to AD progression: Spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers

by Xiao Da, Jon B. Toledo, Jarcy Zee, David A. Wolk, Sharon X. Xie, Yangming Ou, Amanda Shacklett, Paraskevi Parmpi, Leslie Shaw, John Q. Trojanowski, Christos Davatzikos
Published 2014-01-01

ApoE4 effects on automated diagnostic classifiers for mild cognitive impairment and Alzheimer's disease

by Liana G. Apostolova, Kristy S. Hwang, Omid Kohannim, David Avila, David Elashoff, Clifford R. Jack, Jr., Leslie Shaw, John Q. Trojanowski, Michael W. Weiner, Paul M. Thompson
Published 2014-01-01