RPL21 siRNA Blocks Proliferation in Pancreatic Cancer Cells by Inhibiting DNA Replication and Inducing G1 Arrest and Apoptosis

RPL21 siRNA Blocks Proliferation in Pancreatic Cancer Cells by Inhibiting DNA Replication and Inducing G1 Arrest and Apoptosis

BackgroundOur previous study showed that the ribosomal protein L21 (RPL21) may play an important role in the development and survival of pancreatic cancer. In this article, RNA interference (RNAi) experiments were performed with RPL21-specific small interfering RNA (siRNA) to elucidate the mechanism...

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Bibliographic Details
Main Authors: Chaodong Li, Mei Ge, Daijie Chen, Tao Sun, Hua Jiang, Yueqing Xie, Huili Lu, Baohong Zhang, Lei Han, Junsheng Chen, Jianwei Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
RPL21
cell proliferation
cell cycle
cell apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01730/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01730/full

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