Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α.

Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α.

Accumulating evidence implicates the transcriptional coactivator peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α) in the pathophysiology of Huntington Disease (HD). Adult PGC-1α (-/-) mice exhibit striatal neurodegeneration, and reductions in the expression of PGC-1α have been ob...

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Bibliographic Details
Main Authors: Elizabeth K Lucas, Sarah E Dougherty, Laura J McMeekin, Alisa T Trinh, Courtney S Reid, Rita M Cowell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3419240?pdf=render

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http://europepmc.org/articles/PMC3419240?pdf=render

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