PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance

PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance

The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular processes, including the regulation of transcription, apoptosis and the DNA damage response. PARP1 possesses Poly (ADP-ribose) activity and when activated by DNA damage, adds branched PAR chains to facilitate the...

Full description

Bibliographic Details
Main Authors: Maddison Rose, Joshua T. Burgess, Kenneth O’Byrne, Derek J. Richard, Emma Bolderson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
BRCA
PARP inhibitors
DNA damage
DNA repair
cancer
targeted therapy
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.564601/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.564601/full

Similar Items