Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format

Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format

Oncolytic adenoviruses are being developed as new anti-cancer agents. Their efficacy can be improved by incorporating RNA interference (RNAi) molecules. RNAi molecules can be expressed in various precursor formats. The aim of this study was to determine the most effective format. To this end, we con...

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Bibliographic Details
Main Authors: Tereza Brachtlova, Jan-Willem van Ginkel, Mark J. Luinenburg, Renée X. de Menezes, Danijela Koppers-Lalic, D. Michiel Pegtel, Wenliang Dong, Tanja D. de Gruijl, Victor W. van Beusechem
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virus
oncolytic immunotherapy
gene silencing
gene knockdown
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301637

Internet

http://www.sciencedirect.com/science/article/pii/S2372770520301637

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