Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

Trimeric SARS-CoV-2 Spike Proteins Produced from CHO Cells in Bioreactors Are High-Quality Antigens

The spike protein of the pandemic human corona virus is essential for its entry into human cells. In fact, most neutralizing antibodies against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) are directed against the Virus-surface exposed spike protein, making it the antigen of choice...

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Bibliographic Details
Main Authors: Paco Pino, Joeri Kint, Divor Kiseljak, Valentina Agnolon, Giampietro Corradin, Andrey V. Kajava, Paolo Rovero, Ronald Dijkman, Gerco den Hartog, Jason S. McLellan, Patrick O. Byrne, Maria J. Wurm, Florian M. Wurm
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Processes
Subjects:
SARS-CoV-2
trimeric spike
CHO cells
manufacturability
vaccines
diagnostics
Online Access:https://www.mdpi.com/2227-9717/8/12/1539

Internet

https://www.mdpi.com/2227-9717/8/12/1539

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