Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397

Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor, which signals through elevating intracellular cAMP levels, and expressed in most vertebrates, including rodents and humans. In recent years, several lines of evidence indicated the role of TAAR1 in the regulation of dopaminer...

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Bibliographic Details
Main Authors: Stefano Espinoza, Damiana Leo, Tatyana D. Sotnikova, Mohammed Shahid, Tiina M. Kääriäinen, Raul R. Gainetdinov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
ERK
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00645/full