Nucleic acid template and the risk of a PCR-Induced HIV-1 drug resistance mutation.

Nucleic acid template and the risk of a PCR-Induced HIV-1 drug resistance mutation.

The HIV-1 nucleoside RT inhibitor (NRTI)-resistance mutation, K65R confers intermediate to high-level resistance to the NRTIs abacavir, didanosine, emtricitabine, lamivudine, and tenofovir; and low-level resistance to stavudine. Several lines of evidence suggest that K65R is more common in HIV-1 sub...

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Bibliographic Details
Main Authors: Vici Varghese, Elijah Wang, Farbod Babrzadeh, Michael H Bachmann, Rajin Shahriar, Tommy Liu, Svetlana Jean M Mappala, Baback Gharizadeh, W Jeffrey Fessel, David Katzenstein, Seble Kassaye, Robert W Shafer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2881873?pdf=render

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http://europepmc.org/articles/PMC2881873?pdf=render

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