Cytosolic Pellino-1-Mediated K63-Linked Ubiquitination of IRF5 in M1 Macrophages Regulates Glucose Intolerance in Obesity

Cytosolic Pellino-1-Mediated K63-Linked Ubiquitination of IRF5 in M1 Macrophages Regulates Glucose Intolerance in Obesity

IRF5 is a signature transcription factor that induces M1 macrophage polarization. However, little is known regarding cytosolic proteins that induce IRF5 activation for M1 polarization. Here, we report the interaction between ubiquitin E3 ligase Pellino-1 and IRF5 in the cytoplasm, which increased nu...

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Bibliographic Details
Main Authors: Donghyun Kim, Ho Lee, Jaemoon Koh, Jae Sung Ko, Bo Ruem Yoon, Yoon Kyung Jeon, Young Min Cho, Tae Han Kim, Yun-Suhk Suh, Hyuk-Joon Lee, Han-Kwang Yang, Kyong Soo Park, Hye Young Kim, Chang Woo Lee, Won-Woo Lee, Doo Hyun Chung
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
Pellino-1
ubiquitin E3 ligase
IRF5
ubiquitination
macrophages
M1 polarization
cytosolic mediator
glucose metabolism
obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309361

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http://www.sciencedirect.com/science/article/pii/S2211124717309361

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