Intestinal metabolism of baicalein after oral administration in mice: Pharmacokinetics and mechanisms

Intestinal metabolism of baicalein after oral administration in mice: Pharmacokinetics and mechanisms

Baicalein is a dietary flavonoid that exhibits a variety of intestinal pharmacological activities with limited oral bioavailability. In the present study, the intestinal pharmacokinetics of baicalein was determined by HPLC-ESI-MS/MS and HPLC-PDA analysis. After oral administration, the intestinal co...

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Bibliographic Details
Main Authors: Bowei Zhang, Yuesheng Dong, Na Yu, Yuming Sun, Yan Xing, Fan Yang, Xiaoxia Yu, Wenlong Sun, Jin Sun, Xia Li, Zhilong Xiu
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Journal of Functional Foods
Subjects:
Baicalein
Intestinal pharmacokinetics
Phase II metabolism
Gut microbiota
Bioavailability
Flavonoids
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618306753

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http://www.sciencedirect.com/science/article/pii/S1756464618306753

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