NF-κB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity

NF-κB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity

Doxorubicin is a commonly used anthracycline chemotherapeutic agent; however, its application is limited owing to its cardiotoxicity. Current clinical treatments cannot efficiently or fully prevent doxorubicin-induced toxicity, primarily because its pathogenesis and mechanisms of action remain unkno...

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Bibliographic Details
Main Authors: Anji Xu, Feiyan Deng, Yongyi Chen, Yu Kong, Lijun Pan, Qianjin Liao, Zhen Rao, Luyuan Xie, Chaoling Yao, Sha Li, Xiaoling Zeng, Xiaomei Zhu, Huayun Liu, Nina Gao, Lei Xue, Fen Chen, Guoxing Xu, Di Wei, Xiao Zhou, Zan Li, Xiaowu Sheng
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Doxorubicin
Cardiotoxicity
Endothelial-to-mesenchymal transition
Myofibroblast
NF-κB pathway
Cardiac fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220307186

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http://www.sciencedirect.com/science/article/pii/S0753332220307186

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