Connexin 43 impacts on mitochondrial potassium uptake

Connexin 43 impacts on mitochondrial potassium uptake

In cardiomyocytes, connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane, but the protein is also present at the inner membrane of subsarcolemmal mitochondria. Both inhibition and genetic ablation of Cx43 reduce ADP-stimulated complex 1 respiration. Since mitochond...

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Bibliographic Details
Main Authors: Kerstin eBoengler, Elvira eUngefug, Gerd eHeusch, Luc eLeybaert, Rainer eSchulz
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Pharmacology
Subjects:
Connexin 43
Mitochondria, Heart
potassium uptake
Gap19
PBFI
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00073/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00073/full

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