Increasing the power of randomized trials comparing different treatment durations

When the optimal treatment duration is uncertain, a randomized trial may allocate patients to receive active treatment for different durations. We use an example where patients receive treatment for 0, 24, or 52 weeks. In this trial, patients in the 24-weeks and 52-weeks arms receive the same treatm...

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Bibliographic Details
Main Authors: Yongdong Ouyang, Hong Qian, Lakshmi N. Yatham, Hubert Wong
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Contemporary Clinical Trials Communications
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865420300727