An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

Abstract Background The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathogen a priority. Environmental temperature is a key signal which regula...

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Bibliographic Details
Main Authors: Nicola J. Senior, Kalesh Sasidharan, Richard J. Saint, Andrew E. Scott, Mitali Sarkar-Tyson, Philip M. Ireland, Helen L Bullifent, Z. Rong Yang, Karen Moore, Petra C. F. Oyston, Timothy P. Atkins, Helen S. Atkins, Orkun S. Soyer, Richard W. Titball
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Microbiology
Subjects:
Yersinia pestis
Plague
TRADIS
Transposon
Essential genes
Metabolic model
Online Access:http://link.springer.com/article/10.1186/s12866-017-1073-8

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http://link.springer.com/article/10.1186/s12866-017-1073-8

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