The Role of gsp Mutations on the Development of Adrenal Cortical Tumors and Adrenal Hyperplasias

Somatic GNAS point mutations, commonly known as gsp mutations, are involved in the pathogenesis of McCune Albright syndrome and have also been described in autonomous hormone-producing tumors, such as somatotropinoma, corticotrophoma, thyroid cancer, ovarian and testicular Leydig cell tumors and pri...

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Bibliographic Details
Main Authors: Maria Candida Barisson Villares Fragoso, Ingrid Quevedo Wanichi, Isadora Pontes Cavalcante, Beatriz Marinho de Paula Mariani
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Endocrinology
Subjects:
GSP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00104/full