Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage.

Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage.

Gene transfer allows transient or permanent genetic modifications of cells for experimental or therapeutic purposes. Gene delivery by HIV-derived lentiviral vector (LV) is highly effective but the risk of insertional mutagenesis is important and the random/uncontrollable integration of the DNA vecto...

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Bibliographic Details
Main Authors: Nicolas Grandchamp, Dorothée Altémir, Stéphanie Philippe, Suzanna Ursulet, Héloïse Pilet, Marie-Claude Serre, Aude Lenain, Che Serguera, Jacques Mallet, Chamsy Sarkis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4067480?pdf=render

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http://europepmc.org/articles/PMC4067480?pdf=render

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