Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement.

Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement.

HCV infection is often associated with B-cell regulatory control disturbance and delayed appearance of neutralizing antibodies. CD81 is a cellular receptor for HCV and can bind to HCV envelope protein 2 (E2). CD81 also participates to form a B cell costimulatory complex. To investigate whether HCV i...

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Bibliographic Details
Main Authors: Zhihui Chen, Yongzhe Zhu, Yanli Ren, Yimin Tong, Xian Hua, Fenghui Zhu, Libin Huang, Yuan Liu, Yuan Luo, Wei Lu, Ping Zhao, Zhongtian Qi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3079738?pdf=render

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http://europepmc.org/articles/PMC3079738?pdf=render

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