Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC
Botulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membr...
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2017-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-01534-z |
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doaj-1ace838b4bf145588cda2cd87b10cd112021-05-11T07:42:17ZengNature Publishing GroupNature Communications2041-17232017-11-018111210.1038/s41467-017-01534-zStructural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DCSicai Zhang0Ronnie P.-A. Berntsson1William H. Tepp2Liang Tao3Eric A. Johnson4Pål Stenmark5Min Dong6Department of Urology, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Biochemistry and Biophysics, Stockholm UniversityDepartment of Bacteriology, University of WisconsinDepartment of Urology, Boston Children’s Hospital, Harvard Medical SchoolDepartment of Bacteriology, University of WisconsinDepartment of Biochemistry and Biophysics, Stockholm UniversityDepartment of Urology, Boston Children’s Hospital, Harvard Medical SchoolBotulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membranes.https://doi.org/10.1038/s41467-017-01534-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sicai Zhang Ronnie P.-A. Berntsson William H. Tepp Liang Tao Eric A. Johnson Pål Stenmark Min Dong |
spellingShingle |
Sicai Zhang Ronnie P.-A. Berntsson William H. Tepp Liang Tao Eric A. Johnson Pål Stenmark Min Dong Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC Nature Communications |
author_facet |
Sicai Zhang Ronnie P.-A. Berntsson William H. Tepp Liang Tao Eric A. Johnson Pål Stenmark Min Dong |
author_sort |
Sicai Zhang |
title |
Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC |
title_short |
Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC |
title_full |
Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC |
title_fullStr |
Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC |
title_full_unstemmed |
Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC |
title_sort |
structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin dc |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-11-01 |
description |
Botulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membranes. |
url |
https://doi.org/10.1038/s41467-017-01534-z |
work_keys_str_mv |
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1721451725070532608 |