Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC

Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC

Botulinum neurotoxins (BoNTs) are thought to require complex gangliosides, a group of glycosphingolipids, as essential co-receptors to target neurons. Here, the authors show that BoNT/DC represents an exception to this rule and that an extended loop in BoNT/DC penetrates directly into neuronal membr...

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Bibliographic Details
Main Authors: Sicai Zhang, Ronnie P.-A. Berntsson, William H. Tepp, Liang Tao, Eric A. Johnson, Pål Stenmark, Min Dong
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01534-z

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