Spatial Overlap of Claudin- and Phosphatidylinositol Phosphate-Binding Sites on the First PDZ Domain of Zonula Occludens 1 Studied by NMR

Spatial Overlap of Claudin- and Phosphatidylinositol Phosphate-Binding Sites on the First PDZ Domain of Zonula Occludens 1 Studied by NMR

Background: The tight junction is an intercellular adhesion complex composed of claudins (CLDs), occludin, and the scaffolding proteins zonula occludens 1 (ZO-1) and its two paralogs ZO-2 and ZO-3. ZO-1 is a multifunctional protein that contains three PSD95/Discs large/ZO-1(PDZ) domains. A key funct...

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Bibliographic Details
Main Authors: Hidekazu Hiroaki, Kaori Satomura, Natsuko Goda, Yukako Nakakura, Minami Hiranuma, Takeshi Tenno, Daizo Hamada, Takahisa Ikegami
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
phosphoinositide
protein-phospholipid interaction
PDZ domain
tight junction
NMR
chemical shift perturbation
Online Access:http://www.mdpi.com/1420-3049/23/10/2465

Internet

http://www.mdpi.com/1420-3049/23/10/2465

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