Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease. Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly leading to death within ~ 2–5 years of symptomatic onset. There is no cure, and the few available treatments offer o...

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Bibliographic Details
Main Authors: L. McGurk, J. Mojsilovic-Petrovic, V. M. Van Deerlin, J. Shorter, R. G. Kalb, V. M. Lee, J. Q. Trojanowski, E. B. Lee, N. M. Bonini
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Acta Neuropathologica Communications
Subjects:
ABT-888/Veliparib
Parp
Poly(ADP-ribose)
PAR
PARylation
Motor neuron disease, primary neuron
Online Access:http://link.springer.com/article/10.1186/s40478-018-0586-1

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http://link.springer.com/article/10.1186/s40478-018-0586-1

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