Caloric restriction, physical exercise, and CB1 receptor blockade as an efficient combined strategy for bodyweight control and cardiometabolic status improvement in male rats

Abstract Obesity is critically associated with the development of insulin resistance and related cardiovascular and kidney diseases. Several strategies for weight loss have been developed but most of them exhibit a post-intervention rebound effect. Here, we aimed to design combined weight-loss strat...

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Bibliographic Details
Main Authors: Luisa M. Lopez Trinidad, Rosario Martinez, Garyfallia Kapravelou, Milagros Galisteo, Pilar Aranda, Jesus M. Porres, Maria Lopez-Jurado
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83709-9