Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway

Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway

Vascular calcification can be enhanced by hyperglycemia. Elastin loss in tunica media promotes the osteogenic transformation of smooth muscle cells (SMCs) and involves arterial medial calcification (AMC) that is associated with a high incidence of cardiovascular risk in patients with type 2 diabetes...

Full description

Bibliographic Details
Main Authors: Ye-Bo Zhou, Hong Zhou, Li Li, Ying Kang, Xu Cao, Zhi-Yuan Wu, Lei Ding, Gautam Sethi, Jin-Song Bian
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
hydrogen sulfide
calcification
smooth muscle cells
Stat3
cathepsin S
elastin
Online Access:https://www.mdpi.com/1422-0067/20/17/4202

Internet

https://www.mdpi.com/1422-0067/20/17/4202

Similar Items