Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway
Vascular calcification can be enhanced by hyperglycemia. Elastin loss in tunica media promotes the osteogenic transformation of smooth muscle cells (SMCs) and involves arterial medial calcification (AMC) that is associated with a high incidence of cardiovascular risk in patients with type 2 diabetes...
Main Authors: | Ye-Bo Zhou, Hong Zhou, Li Li, Ying Kang, Xu Cao, Zhi-Yuan Wu, Lei Ding, Gautam Sethi, Jin-Song Bian |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-08-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/17/4202 |
Similar Items
-
Identification of potential exosite in cathepsin V necessary for elastin degradation
by: Chen, Li Hsuen
Published: (2009) -
Identification of potential exosite in cathepsin V necessary for elastin degradation
by: Chen, Li Hsuen
Published: (2009) -
Identification of potential exosite in cathepsin V necessary for elastin degradation
by: Chen, Li Hsuen
Published: (2009) -
Association between serum elastin-derived peptides and abdominal aortic calcification in peritoneal dialysis patients: a cross-sectional study
by: Shizhu Zhao, et al.
Published: (2021-01-01) -
Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease
by: Brena F. Sena, et al.
Published: (2018-01-01)