Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers

Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers

Abstract Background Inflammatory breast cancer (IBC) has a highly invasive and metastatic phenotype. However, little is known about its genetic drivers. To address this, we report the largest cohort of whole-genome sequencing (WGS) of IBC cases. Methods We performed WGS of 20 IBC samples and paired...

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Bibliographic Details
Main Authors: Xiaotong Li, Sushant Kumar, Arif Harmanci, Shantao Li, Robert R. Kitchen, Yan Zhang, Vikram B. Wali, Sangeetha M. Reddy, Wendy A. Woodward, James M. Reuben, Joel Rozowsky, Christos Hatzis, Naoto T. Ueno, Savitri Krishnamurthy, Lajos Pusztai, Mark Gerstein
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Genome Medicine
Subjects:
Inflammatory breast cancer
Whole-genome sequencing
Single nucleotide variant
Copy number variant
Structural variant
Online Access:https://doi.org/10.1186/s13073-021-00879-x

Internet

https://doi.org/10.1186/s13073-021-00879-x

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