Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy

Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy

TB control is limited in part by the length of antibiotic treatment needed to prevent recurrent disease. To probe mechanisms underlying survival under antibiotic pressure, we performed a genetic screen for M. tuberculosis mutants with altered susceptibility to treatment using the mouse model of TB....

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Bibliographic Details
Main Authors: Michelle M. Bellerose, Seung-Hun Baek, Chuan-Chin Huang, Caitlin E. Moss, Eun-Ik Koh, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Jong Seok Lee, Seokyong Eum, Sung Jae Shin, Sang-Nae Cho, Megan Murray, Christopher M. Sassetti
Format: Article
Language:English
Published: American Society for Microbiology 2019-07-01
Series:mBio
Subjects:
mycobacterium tuberculosis
antibiotic resistance
genetics
Online Access:https://doi.org/10.1128/mBio.00663-19

Internet

https://doi.org/10.1128/mBio.00663-19

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