Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle

Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle

We previously found that a nanoparticle constructed with an antigen, benzalkonium chloride (BK) and γ-polyglutamic acid (γ-PGA) showed high Th1 and Th2-type immune induction after subcutaneous administration. For prophylaxis of respiratory infections, however, mucosal immunity should be induced. In...

Full description

Bibliographic Details
Main Authors: Tomoaki Kurosaki, Yuki Katafuchi, Junya Hashizume, Hitomi Harasawa, Hiroo Nakagawa, Mikiro Nakashima, Tadahiro Nakamura, Chikamasa Yamashita, Hitoshi Sasaki, Yukinobu Kodama
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
vaccine
pulmonary administration
nanoparticles
γ-polyglutamic acid
mucosal immunity
Online Access:http://dx.doi.org/10.1080/10717544.2021.1955040

Internet

http://dx.doi.org/10.1080/10717544.2021.1955040

Similar Items